1. Fan, C.-M. and Maniatis, T. (1989). Two different virus-inducible elements are required for beta-interferon gene regulation. EMBO J. 8, 101-110.
  2. Lenardo, M.J., Fan, C.-M., Maniatis, T. and Baltimore, D. (1989). The involvement of NF-kappa-B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell 57, 287-294.
  3. Fan, C.-M. and Maniatis, T. (1990). A DNA binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. Genes & Development 4, 29-42.
  4. Fan, C.-M. and Maniatis, T. (1991). The p50 subunit of NF-kappa-B is generated by processing of p105 through an ATP-dependent pathway. Nature 354, 395-398.
  5. Maniatis, T., Whittemore, L.-A., Du, W., Fan, C.-M., Keller, A., Palombella, V.J. Thanos, D.N. (1992). Positive and Negative Control of Human Interferon- Gene Expression. Harvey Lecture 44, 1193-1220. Cold Spring Harbor Press.
  6. Fan, C.-M. and Tessier-Lavigne, M. (1994). Patterning of Mammalian Somites by the Surface Ectoderm and the Notochord: Evidence for Sclerotome Induction by a Hedgehog Homolog. Cell 79, 1175-1186.
  7. Fan, C.-M., Porter, J., Chiang, C., Chang, D.T., Beachy, P.A., and Tessier-Lavigne, M. (1995). Long-Range Sclerotome Induction by Sonic Hedgehog: Direct Role of the Amino-Terminal Cleavage Product and Modulation by the cyclic-AMP Signaling Pathway. Cell 81, 457-465.
  8. Muenke, M., Bone, L., Mitchell, H., Hart, I., Walton, K., Hall-Johnson, K., Ippel. E., Dietz-Band, J., Karloy, K., Fan, C.-M., Tessier-Lavigne, M., and Patterson, D. (1995). Physical Mapping of the Holoprosencephaly Critical Region in 21q22.3, Exclusion of SIM2 as a Candidate Gene for HPE, and Mapping of SIM2 to a Region of Chromosome 21 Important for Down Syndrome. The American Journal of Human Genetics 57, 1074-1079
  9. Pourquie, O., Fan, C.-M., Coltey, M., Hirsinger, E., Watanabe, Y., Breant, C., Francis-West, P., Brickell, P., Tessier-Lavigne, M., and Le Douarin, N.M. (1996). Lateral and Axial Signals involved in Avian Somite Patterning : Role of the BMP4 Protein. Cell 84, 461-471.
  10. Fan, C.-M., Kuwana, E., Bulfone, A., Fletcher, C. F., Copeland, N. G., Jenkins, N. A., Crews, S., Salvador, M., Puelles, L., Rubenstein, J. L. R., and Tessier-Lavigne, M. (1996). Expression Patterns of Two Murine Homologs of Drosophila single-minded Suggest Possible Roles in Embryonic Patterning and in the Pathogenesis of Down Syndrome. Molecular and Cellular Neuroscience 7, 1-16.
  11. Mastick, G.S., Fan, C.-M., Tessier-Lavigne, M., Serbedzija, G.N., MaMahon, A.P., Easter, S.S., Jr. (1996). Early Deletion of Neuromeres in Wnt-1-/- Mutant Mice: Evaluation by Morphological and Molecular Markers. The Journal of Comparative Neurology 374, 246-258.
  12. Probst, M.R., Fan, C.-M.,Tessier-Lavigne, M., and Hankinson, O. (1997). Two Murine Homologs of the Drosophila single-minded Protein that Interact with the Mouse Aryl Hydrocarbon Receptor Nuclear Translocator Protein. Journal of Biological Chemistry 272, 4451-4457.
  13. Michaud, J. and Fan, C.-M. (1997). Single-minded - Two Genes, Three Chromosomes. Genome Research 7, 569-571.
  14. Fan, C.-M., Lee, C.S., and Tessier-Lavigne, M. (1997) A Role for WNT Proteins in Induction of Dermomyotome. Developmental Biology 191, 160-165.
  15. McMahon, J., Takada, S., Zimmerman, L.B., Fan, C.-M., Harland, R.M., and McMahon, A.P. (1998) Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes & Development 12, 1438-1452.
  16. Michaud, J., Rosenquist, T., May, N.R., and C.-M. Fan. (1998). Development of neuroendocrine lineages requires the BHLH-PAS transcription factor SIM1. Genes & Development 12, 3264-3275.
  17. Lee, C.S., Buttitta, L., May, N.R., Kispert, A., and C.-M. Fan. (2000). SHH-N upregulates Sfrp2 in the somitic mesoderm to mediate its competitive action with WNT1 and WNT4. Development 127, 109-118.
  18. Michaud, J.L., De Rossi, C., May, N.R., Holdener, B., and C.-M. Fan. (2000). ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus. Mechanism of Development 90, 253-261.
  19. Epstein, D.J., Martinu, L., Michaud, J.L., Losos, K.M., Fan, C.-M., and A.-L. Joyner. (2000). Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS.
    Development 127, 4701-4709.
  20. Lee, S.C. and C.-M. Fan. (2001). Embryonic expression patterns of the mouse and chick Gas1 genes. Mechanism of Development 101, 293-297.
  21. Lee, C.S., May, N.R., and C.-M. Fan. (2001). Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the Graowth Arrest Specific Gene 1 mutant. Developmental Biology 236, 17-29.
  22. Liu, Y., May, N.R., C.-M. Fan. (2001). Growth Arrest Specific Gene 1 is a positive growth regulator for the cerebellum. Developmental Biology 236, 30-45.
  23. Lee, C.S., Buttitta, L., and C.-M. Fan. (2001). Evidence that the WNT-inducible growth arrest specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite. Proc. Natl. Acad. Sci. USA 98, 11347-11352.
  24. Michaud, J.L., Boucher, F., Melnyk, A., Gauthier, F, Goshu, E., Levy, E., Mitchell, G.A., Himms-Hagen, J., and C.-M. Fan. (2001). Human Molecular Genetics 10, 1465-1473.
  25. Goshu, E. Jin, H., Fasnacht, R., Spenski, M., Michaud, J.L., and C.-M. Fan. (2002). Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants. Mol.Cell. Biol. 22, 4147-4157.
  26. Liu, Y., Liu, C., Yamada, Y., and C.-M. Fan. (2002). Growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb. Development 129, 5289-5300.
  27. Buttitta, L., Tanaka, T., Chen, A., Ko, M., and C.-M. Fan. (2003) Microarray analysis reveals novel WNT targets in the somites. Developmental Biology 258, 91-104.
  28. Liu C, Goshu E, Wells A, Fan CM. (2003) Identification of the downstream targets of SIM1 and ARNT2, a pair of transcription factors essential for neuroendocrine cell differentiation. J Biol Chem. 278:44857-67.
  29. Buttitta L, Mo R, Hui CC, Fan CM. (2003) Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130:6233-43.
  30. Goshu E, Jin H, Lovejoy J, Marion JF, Michaud JL, Fan CM. (2004) Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus. Mol Endocrinol. 18:1251-62.
  31. Chen AE, Ginty DD, Fan CM. (2005) Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. Nature 433: 208-9.
  32. Chen AE, Fan CM. (2005) Targeting gene expression in the mouse somite: adenovirus-mediated gene delivery and whole embryo culture. Genesis 42:71-6.
  33. Xu, C. and Fan, C.-M. (2007) Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1. Molecular Endocrinology 21, 1234-1245.
  34. Martinelli, D.C. and Fan, C.-M. (2007) Gas1 extends the range of Hedgehog action by facilitating its signaling.Genes & Development 15, 1231-1243.
  35. Seppala, M., Depew, M.J., Martinelli, D.C., Fan, C.-M., Sharpe P.T., and Cobourne M.T. (2007) Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog. Journal of Clinical Investigation 117, 1575-1584.
  36. Martinelli, D.C. and Fan, C.M. (2007) The role of Gas1 in embryonic development and its implications for human disease. Cell Cycle 6, 2650-2655.
  37. Friedman, E.R. and Fan, C.-M. (2007) Separate Necdin domains bind ARNT2 and HIF1a and repress transcription. Biochemical Biophysical Research Communications 63, 113-118.
  38. Xu, C. and Fan, C.-M. (2008) Neuropilin, Plexin, and Semaphorin family members are expressed in the developing hypothalamus. Gene expression patterns 8, 502-507.
  39. Zhang, Y., Narayan, S., Geiman, E., Lanuza, G. M., Velasquez, T., Shanks, B., Akay, T., Dyck, J., Pearson, K., Gosgnach, S., Fan, C.-M., and Goulding, M. (2008) V3 spinal neurons establish a robust and balanced locomotor rhythm during walking Neuron 60, 84-95.
  40. Ohazama, A., Haycraft, C.J., Seppala, M., Blackburn, J., Cobourne, M., Ghafoor, S., Martinelli, D., Fan, C.-M., Peterkova, R., Lesot, H., Yoder, B.K., and Sharpe, P.T. (2009) Primary cilia regulate Shh activity in the control of molar tooth number. Development 136, 897-903.
  41. Martinelli, D.C. and Fan, C.-M. (2009) A sonic hedgehog missense mutation associated with holoprocensephaly causes defective binding to Gas1. Journal of Biological Chemistry 284, 19169-19172.
  42. Lepper, C., Conway, S, and Fan, C.-M. (2009) Adult muscle stem cells have distinct genetic requirement from embryonic and neonatal progenitors. Nature 460, 627-631.
  43. Vong QP, Liu Z, Yoo JG, Chen R, Xie W, Sharov AA, Fan CM, Liu C, Ko MS, Zheng Y. (2010) A role for borg5 during trophectoderm differentiation. Stem Cells. 2010 Jun;28(6):1030-8.
  44. Spradling A, Fan CM. (2010) Counterfeiting the family jewels. Cell Stem Cell. 2010 May 7;6(5):405-6.
  45. Christoph Lepper, Chen-Ming Fan. (2010) Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells. Genesis. 2010 Jul ;48(7), 424-436
  46. Osterberg N, Wiehle M, Oehlke O, Heidrich S, Xu C, Fan CM, Krieglstein K, Roussa E. (2011) Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons. PLoS One, 6: e19239.
  47. Pineda-Alvarez DE, Roessler E, Hu P, Srivastava K, Solomon BD, Siple CE, Fan CM, Muenke M. (2011)Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH.  Hum Genet, Aug 13. PMID:21842183.
  48. Lepper C, Partridge TA, Fan CM. (2011) An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration. Development, 138: 3639-3646.
  49. Kim Y, Sharov AA, McDole K, Cheng M, Hao H, Fan CM, Gaiano N, Ko MS, Zheng Y. (2011) Mouse B-Type Lamins Are Required for Proper Organogenesis But Not by Embryonic Stem Cells. Science, Nov 24. PMID:22116031.
  50. Lopez TP, Fan CM. (2011) A transgenic Tbx6;CreER(T2) line for inducible gene manipulation in the presomitic mesoderm. Genesis, Nov 26. PMID:22121035.
  51. Lepper C, Fan CM. (2012) Generating tamoxifen-inducible cre alleles to investigate myogenesis in mice.Methods Mol Biol, 798: 297-308.
  52. Fan Chen‐Ming, Li Lydia, Rozo Michelle E., Lepper Christoph. Making skeletal muscle from progenitor and stem cells: development versus regeneration. WIREs Dev Biol 2012. doi: 10.1002/wdev.30
  53. Havis E, Coumailleau P, Bonnet A, Bismuth K, Bonnin MA, Johnson R, Fan CM, Relaix F, Shi DL, Duprez D.Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis. Development. 2012 Apr 18. PMID: 22513369
  54. Se-Jin Lee, Thanh V. Huynh, Yun-Sil Lee, Suzanne M. Sebald, Sarah A. Wilcox-Adelman, Naoki Iwamori, Christoph Lepper, Martin M. Matzuk, and Chen-Ming Fan. PNAS Plus: Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway PNAS 2012 ; published ahead of print August 6, 2012, doi:10.1073/pnas.1206410109
  55. Biau S, Jin S, Fan CM. Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling. Biol Open. 2013 Feb 15;2(2):144-55. doi: 10.1242/bio.20123186. Epub 2012 Nov 20. PMID: 23429478
  56. Khonsari RH, Seppala M, Pradel A, Dutel H, Clément G, Lebedev O, Ghafoor S, Rothova M, Tucker A, Maisey JG, Fan CM, Kawasaki M, Ohazama A, Tafforeau P, Franco B, Helms J, Haycraft CJ, David A, Janvier P, Cobourne MT, Sharpe PT. The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling. BMC Biol. 2013 Mar 28;11:27. doi: 10.1186/1741-7007-11-27. PMID: 23537390
  57. Gurung B, Feng Z, Iwamoto DV, Thiel A, Jin G, Fan CM, Ng JM, Curran T, Hua X. Menin Epigenetically Represses Hedgehog Signaling in MEN1 Tumor Syndrome. Cancer Res. 2013 Apr 15;73(8):2650-8. doi: 10.1158/0008-5472.CAN-12-3158. Epub 2013 Apr 11. PMID: 23580576
  58. Lopez TP, Fan CM. Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis. Proc Natl Acad Sci U S A. 2013 May 13. [Epub ahead of print] PMID: 23671110
  59. Minchin JE, Williams VC, Hinits Y, Low S, Tandon P, Fan CM, Rawls JF, Hughes SM. (2013) Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion. Development Jun 12. [Epub ahead of print] PMID:23760954
  60. Günther S, Kim J, Kostin S, Lepper C, Fan CM, Braun T. (2013) Myf5-Positive Satellite Cells Contribute to Pax7-Dependent Long-Term Maintenance of Adult Muscle Stem Cells.
    Cell Stem Cell. Aug 6. pii: S1934-5909(13)00324-X. doi: 10.1016/j.stem.2013.07.016. [Epub ahead of print]
  61. Distinct and Overlapping Sarcoma Subtypes Initiated from Muscle Stem and Progenitor Cells.
    Blum JM, Añó L, Li Z, Van Mater D, Bennett BD, Sachdeva M, Lagutina I, Zhang M, Mito JK, Dodd LG, Cardona DM, Dodd RD, Williams N, Ma Y, Lepper C, Linardic CM, Mukherjee S, Grosveld GC, Fan CM, Kirsch DG. Cell Rep. 2013 Nov 13. doi:pii: S2211-1247(13)00604-9. 10.1016/j.celrep.2013.10.020. [Epub ahead of print] PMID:24239359
  62. Webster, M.T. and Fan, C.-M. (2013) c-MET Regulates Myoblast Motility and Myocyte Fusion during Adult Skeletal Muscle Regeneration. PLOS ONE, DOI: 10.1371/journal.pone.0081757
  63. WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals.
    Kann M, Bae E, Lenz MO, Li L, Trannguyen B, Schumacher VA, Taglienti ME, Bordeianou L, Hartwig S, Rinschen MM, Schermer B, Benzing T, Fan CM, Kreidberg JA.
    Development. 2015 Apr 1;142(7):1254-66. doi: 10.1242/dev.119735.
    PMID: 25804736
  64. Jin, S., Martinelli, D.C., Zheng, X., Tessier-Lavigne, M., and Fan, C.-M. (2015) Gas1 is a receptor for sonic hedgehog to repel enteric axons. Proc. Nat. Acad. Sci. 112, E73-80.
  65. Van Mater, D., Añó, L., Blum, J.M., Webster, M.T., Huang, W., Williams, N., Ma, Y., Cardona, D.M., Fan, C.-M., and Kirsch, D.G. (2015) Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway. Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway. Cancer Research 753, 605-14.
  66. HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration.
    Choi MC, Ryu S, Hao R, Wang B, Kapur M, Fan CM, Yao TP.
    EMBO Rep. 2014 Nov;15(11):1175-83. doi: 10.15252/embr.201439195. Epub 2014 Sep 9.
    PMID: 25205686
  67. Boc modifies the spectrum of holoprosencephaly in the absence of Gas1 function.
    Seppala M, Xavier GM, Fan CM, Cobourne MT.
    Biol Open. 2014 Jul 25;3(8):728-40. doi: 10.1242/bio.20147989.
    PMID: 25063195
  68. A series of Cre-ER(T2) drivers for manipulation of the skeletal muscle lineage.
    Southard S, Low S, Li L, Rozo M, Harvey T, Fan CM, Lepper C.
    Genesis. 2014 Aug;52(8):759-70. doi: 10.1002/dvg.22792. Epub 2014 Jun 3.
    PMID: 24844572
  69. Kann, M., Bae, E., Lenz, M.O., Li, L., Trannguyen, B., Schumacher, V.A., Taglienti, M.E., Bordeianou, L., Hartwig, S., Rinschen, M.M., Schermer, B., Benzing, T., Fan, C.-M., and Kreidberg, J.A. (2015) WT1 targets Gas1 to maintain nepheron progenitor cells by modulating FGF signals. Development 142, 1254-66.
  70. Ren, R.A., Liu, Z., Mullany, L.K., Fan, C.-M., and Richards, J.S. (2016) Growth arrest specific-1 (Gas1) is a C/EBP target gene that functions in ovulation and corpus luteum formation in mice. Biol. Reprod. 94, 44.
  71. Webster, M.T., Manor, U., Lippincott-Schwartz, J., and Fan, C.-M. (2016) Intravital imaging reveals ghost fibers as architectural units guiding myogenic progenitors during regeneration. Cell Stem Cell 18, 243-52.
  72. Targeting β1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice.
    Rozo M, Li L, Fan CM.
    Nat Med. 2016 Jul 4. doi: 10.1038/nm.4116. [Epub ahead of print]
    PMID: 27376575
  73. Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice.
    Lukjanenko L, Jung MJ, Hegde N, Perruisseau-Carrier C, Migliavacca E, Rozo M, Karaz S, Jacot G, Schmidt M, Li L, Metairon S, Raymond F, Lee U, Sizzano F, Wilson DH, Dumont NA, Palini A, Fässler R, Steiner P, Descombes P, Rudnicki MA, Fan CM, von Maltzahn J, Feige JN, Bentzinger CF.
    Nat Med. 2016 Jul 4. doi: 10.1038/nm.4126. [Epub ahead of print]
    PMID: 27376579
  74. Li, L. and Fan, C.-M. (2017) A CREB-MPP7-AMOT Regulatory Axis Controls Muscle Stem Cell Expansion and Self-Renewal Competence. Cell Rep. 2017 Oct 31;21(5):1253-1266. doi: 10.1016/j.celrep.2017.10.031.

  75. Low, SH. and Fan, C.-M. (2017) Interleukins 4 and 13 Induce Exon Skipping of Mutant Dystrophin Pre-mRNA to Restore Dystrophin Production. bioRxiv, doi: https://doi.org/10.1101/207480 

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Chen-Ming Fan