Articles

Malki, S., Tharp, M.E., Bortvin, A.  
A Whole-Mount Approach for Accurate Quantitative and Spatial Assessment of Fetal Oocyte Dynamics in Mice.
Biology of Reproduction, (2015), in press.

Gaysinskaya, V., Bortvin, A.
Flow Cytometry of Murine Spermatocytes
Curr. Protoc. Cytom. (2015) 72:7.44.1-7.44.24

Genzor, P., Bortvin, A.
A unique HMG-box domain of mouse Maelstrom binds structured RNA but not double stranded DNA.
PLOS ONE. (2015) 10(3):e0120268

Castaneda, J., Genzor, P., van der Heijden, G.W., Sarkeshik, A., Yates, J.R., Ingolia, N.T., Bortvin, A.
Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice.
The EMBO Journal. (2014) 33(18):1999-2019
Dropbox Download
-- Accompanied by a Preview "Primary piRNA biogenesis: caught up in a Maelstrom"

Malki, S., van der Heijden, G.W., O'Donnell, K.A., Martin, S.L., Bortvin, A.
A Role for Retrotransposon LINE-1 in Fetal Oocyte Attrition in Mice
Developmental Cell. (2014) 29(5):521-33
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-- Accompanied by Preview "LINE-1 of Evidence for Fetal Oocyte Attrition by Retrotransposon" by S. Chuma.
-- Also described in "World of Reproductive Biology: Retrotransposons May Kill Off Fetal Oocytes" by C. Schubert at Biology of Reproduction.

Gaysinskaya, V, Soh, I.Y., van der Heijden, G.W., Bortvin, A.
Optimized flow cytometry isolation of murine spermatocytes.
Cytometry A. (2014) 85(6):556-65
-- Accompanied by a commentary "Sorting Out Meiosis" by David Stuart

Guan, L., van der Heijden, G.W., Bortvin, A.*, Greenberg, M.M.*
Intracellular detection of Cytosine incorporation in genomic DNA by using 5-ethynyl-2'-deoxycytidine.
Chembiochem. (2011) 12(14):2184-90.
-- Designated as "VIP" - a very important paper by the journal

Vranis, N.M., van der Heijden, G.W., Malki, S., Bortvin, A.
Synaptonemal Complex Length Variation in Wild-Type Male Mice.
Genes. (2010) 1(3):505-520

Aravin, A.A., van der Heijden, G.W., Castaneda, J., Vagin, V.V., Hannon, G.J., Bortvin, A.
Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice.
PLoS Genet. (2009) 5(12):e1000764
-- Accompanied by Perspective "Retrotransposon Silencing by piRNAs: Ping-Pong Players Mark Their Sub-Boundaries" by S. Chuma and R. Pillai

Soper, S.F.C., van der Heijden, G.W., Hardiman, T.C., Goodheart, M., Martin, S.L., de Boer, P., Bortvin, A.
Mouse Maelstrom, a Component of Nuage, Is Essential for Spermatogenesis and Transposon Repression in Meiosis.
Developmental Cell. (2008) 15(2):285-297
-- Accompanied by a Comment "A Descent Into the Nuage: the Maelstrom of Transposon Control" by K. A. O'Donnell, K.H. Burns and J.D. Boeke.

Bortvin, A., Goodheart, M., Liao, M., Page, D.C.
Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice.
BMC Dev Biol. 2004 Feb 23;4(1):2.
-- An "All time highly accessed" article at BMC Developmental Biology

Bortvin, A., Eggan, K., Skaletsky, H., Akutsu, H., Berry, D.L., Yanagimachi, R., Page, D.C., Jaenisch, R.
Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.
Development. (2003) 130(8):1673-80.
-- Highlighted in Nature's "News and Views" commentary "Gene Expression: Silent Clones Speak Up" by W. Reik and W. Dean

Reviews

Bortvin, A.
PIWI-interacting RNAs (piRNAs) - a mouse testis perspective
Biochemistry (Mosc.) (2013) 78(6):592-602

Castaneda, J., Genzor, P., Bortvin, A.
piRNAs, transposon silencing, and germline genome integrity.
Mutat Res. (2011) 714(1-2):95-104.

van der Heijden, G.W., Castaneda, J., Bortvin, A.
Bodies of evidence - compartmentalization of the piRNA pathway in mouse fetal prospermatogonia.
Curr Opin Cell Biol. (2010) 22(6):752-7.

van der Heijden G. W., Bortvin, A.
Defending the Genome in Tudor Style.
Developmental Cell (2009) 17(6):745-6

van der Heijden, G.W., Bortvin, A.
Transient relaxation of transposon silencing at the onset of mammalian meiosis.
Epigenetics (2009) 4(2):76-9.

 

Lab: 
Reference to Person: 
Alex Bortvin