Baltimore, MD— As we age, the function and regenerative abilities of skeletal muscles deteriorate, which means it is difficult for the elderly to recover from injury or surgery. New work from Carnegie’s Michelle Rozo, Liangji Li, and Chen-Ming Fan demonstrates that a protein called b1-integrin is crucial for muscle regeneration. Their findings, published by Nature Medicine, provide a promising target for therapeutic intervention to...
Baltimore, MD— Tiny transparent zebrafish are changing lives through the BioEYES program. A former BioEYES student in Baltimore, Sih Oka Zeh, shared that BioEYES was the catalyst for following a career path in the sciences: “I had BioEYES in 7th grade. Before they came I was told we were going to do an experiment with fish and microscopes. I wasn’t interested. But then they showed up with all this equipment I’d never seen...
Baltimore, MD—New work from Carnegie’s Allan Spradling and Lei Lei demonstrates that mammalian egg cells gain crucial cellular components at an early stage from their undifferentiated sister cells, called germ cells. This mechanism had previously only been documented in lower animals, and may be a key to understanding the egg’s unique properties. Their work is published via Science First Release. Egg cells are the only cells in...
Washington, D.C.—Matthew Sieber, a postdoctoral fellow at the Department of Embryology, has been honored for his extraordinary accomplishments, through a new program that recognizes exceptional Carnegie postdoctoral scholars who have demonstrated both scientific accomplishments and creative endeavors beyond what is expected. Nominations for the Postdoctoral Innovation and Excellence (PIE) Awards are made through the department directors,...
Baltimore, MD— Reproduction is highly dependent on diet and the ability to use nutrients to grow and generate energy. This is clearly seen in women, who must provide all the nutritional building blocks required to support a growing embryo. As a result, metabolic diseases like diabetes and obesity are closely linked with several female reproductive disorders such as: Infertility, polycystic ovary syndrome, and ovarian cancer. However, the...
San Diego, CA— Ghosts are not your typical cell biology research subjects. But scientists at the Carnegie Institution for Science and the National Institute of Child Health and Human Development (NICHD) who developed a technique to observe muscle stem/progenitor cells migrating within injury sites in live mice, report that “ghost fibers,” remnants of the old extracellular matrix left by dying muscle fibers, guide the cells into...
Baltimore, MD – On November 12, 2015, students from ConneXions Academy will address water-quality issues in Baltimore through the General Motors Global Rivers Environmental Education Network (GM GREEN) managed by the Earth Force program, part of Carnegie’s BioEYES’ Your Watershed, Your Backyard education effort. Students will partner with engineers on Gwynns Falls Trail, Leakin Park in Baltimore, from 10 am to noon. The media...
The American Society for Cell Biology profiles Yixian Zheng and her recent papers on the elusive spindle matrix. "Zheng’s lab identifies new regulators in spindle assembly, all associated with the spindle matrix, a structural scaffold that promotes mitosis.The problem here is that some scientists aren’t convinced that the spindle matrix exists. In one of these new papers, Zheng begs to differ." More
Two researchers, Martin Jonikas of Carnegie’s Department of Plant Biology and Zhao Zhang of the Department of Embryology, have been awarded the New Innovator and Early Independence Awards, respectively, from the National Institutes of Health (NIH). Traditionally, NIH has supported research projects, not individuals. However, “to identify scientists with ideas that have the potential for high impact, but that may be too novel, span...
Baltimore, MD— Every high school biology class learns about the tiny cells that comprise our bodies, as well as about many of the diverse actions that they perform. One of these actions is called mitosis, the series of steps through which a cell divides itself into two daughter cells, each of which has the same genetic material. Mitosis involves copying or “replicating” each of the cell’s DNA-containing chromosomes,...
Baltimore, MD— The Farber lab's own Oscar Reyes is the recipient of the 2015 Danny Lee Award from Johns Hopkins University. The Danny Lee Award is presented to deserving graduating Undergraduates who show outstanding promise, talent, motivation and achievement in scientific research. This award was established at the request of Hsiao Yu (Danny) Lee's parents to honor his memory by helping people who share the same goals and love of science as...
Baltimore, MD—Carnegie’s BioEYES K-12 science educational program launches a new center sponsored by the University of Utah, Department of Pediatrics, Pediatric Research Enterprise. The new program manager and educator of BioEYES Utah, Judith Neugebauer, will use her zebrafish research experience to introduce students to the scientific method with a hands-on learning opportunity to watch live, transparent, zebrafish embryos develop....
Allan Spradling offers input to The Scientist on a paper about female Japanese rice fish producing sperm. More
Mitotic proteins take on editorial duties in this writeup of new work from Yixian Zheng's lab in The Journal of Cell Biology. More 
Baltimore, MD— Nutrition and metabolism are closely linked with reproductive health. Several reproductive disorders including polycystic ovary syndrome, amenorrhea, and ovarian cancer have been linked to malnutrition, diabetes, and obesity. Furthermore, fasting in numerous species can result in decreased fertility, because the development of immature egg cells, called oocytes, is arrested. Understanding how nutrients accumulate in immature...
Baltimore, MD—The newest member of the staff at the Carnegie Department of Embryology, Junior Investigator Zhao Zhang, received the prestigious Larry Sandler Memorial Award at the 56th Annual Drosophila Research Conference of the Genetics Society of America in Chicago the first week of March. The annual award is given for the best research that led to a Ph. D. using Drosophila, the genetically tractable fruit fly that is employed in a wide...
Baltimore MD— We would not expect a baby to join a team or participate in social situations that require sophisticated communication. Yet, most developmental biologists have assumed that young cells, only recently born from stem cells and known as “progenitors,” are already competent at inter-communication with other cells. New research from Carnegie’s Allan Spradling and postdoctoral fellow Ming-Chia Lee shows that...
Tuesday, November 25, 2014, Baltimore, MD—Biologist Marnie Halpern of Carnegie’s Department of Embryology has been named a Fellow of the American Association for the Advancement of Science (AAAS) for her “fundamental contributions to developmental biology, particularly using novel genetic approaches to study patterning of the nervous system.” Halpern has been a staff scientist at Carnegie since1994. Using the tiny...
Baltimore, MD—As animals age, their immune systems gradually deteriorate, a process called immunosenescence. It is associated with systemic inflammation and chronic inflammatory disorders, as well as with many cancers. The causes underlying this age-associated inflammation, and how it leads to diseases, are poorly understood. New work in Carnegie’s Yixian Zheng’s lab sheds light on one protein’s involvement in suppressing...
Baltimore, MD--The General Motors Corporation is presenting a $5,000.00 award to Carnegie’s BioEYES K-12 educational program on September 11, 2014, to deliver a two-week environmental curriculum, Your Watershed, Your Backyard. The program, established in 2008, is one of several BioEYES programs using live zebrafish in a hands-on approach to learning and focuses on local watersheds, pollution, and the Chesapeake Bay. The event includes other...
Baltimore, MD— A woman’s supply of eggs is a precious commodity because only a few hundred mature eggs can be produced throughout her lifetime and each must be as free as possible from genetic damage. Part of egg production involves a winnowing of the egg supply during fetal development, childhood and into adulthood down from a large starting pool. New research by Carnegie’s Alex Bortvin and postdoctoral fellow Safia Malki have gained new...
Audio Baltimore, MD—Exposure to environmental endocrine disrupters, such as bisphenol A, which mimic estrogen, is associated with adverse health effects. Bisphenol A is commonly found in plastic bottles and plastic food containers. New research from a team including Carnegie's Daniel Gorelick and Marnie Halpern on the effects of these chemicals on zebrafish shows that embryonic heart valves could be particularly in danger. It is published by...
YouTubeBaltimore, MD— As all school-children learn, cells divide using a process called mitosis, which consists of a number of phases during which duplicate copies of the cell's DNA-containing chromosomes are pulled apart and separated into two distinct cells. Losing or gaining chromosomes during this process can lead to cancer and other diseases, so understanding mitosis is important for developing therapeutic strategies. New research from a...
AudioBaltimore, MD— One classical question in developmental biology is how different tissue types arise in the correct position of the developing embryo. While one signaling pathway that controls this process has been well described, unexpected findings from a team led by Carnegie’s Steven Farber reveal the importance of polyunsaturated fatty acid metabolism in this process. It is published online December 12 in Developmental Cell. Fatty acids...
AudioBaltimore, MD—In researching neural pathways, it helps to establish an analogous relationship between a region of the human brain and the brains of more-easily studied animal species. New work from a team led by Carnegie’s Marnie Halpern hones in on one particular region of the zebrafish brain that could help us understand the circuitry underlying nicotine addiction. It is published the week of December 9 by Proceedings of the National...