Baltimore, MD—The newest member of the staff at the Carnegie Department of Embryology, Junior Investigator Zhao Zhang, received the prestigious Larry Sandler Memorial Award at the 56th Annual Drosophila Research Conference of the Genetics Society of America in Chicago the first week of March. The annual award is given for the best research that led to a Ph. D. using Drosophila, the genetically tractable fruit fly that is employed in a wide range...
Baltimore MD— We would not expect a baby to join a team or participate in social situations that require sophisticated communication. Yet, most developmental biologists have assumed that young cells, only recently born from stem cells and known as “progenitors,” are already competent at inter-communication with other cells. New research from Carnegie’s Allan Spradling and postdoctoral fellow Ming-Chia Lee shows that infant cells have to go...
Tuesday, November 25, 2014, Baltimore, MD—Biologist Marnie Halpern of Carnegie’s Department of Embryology has been named a Fellow of the American Association for the Advancement of Science (AAAS) for her “fundamental contributions to developmental biology, particularly using novel genetic approaches to study patterning of the nervous system.” Halpern has been a staff scientist at Carnegie since1994. Using the tiny zebrafish, Danio rerio, Halpern...
Baltimore, MD—As animals age, their immune systems gradually deteriorate, a process called immunosenescence. It is associated with systemic inflammation and chronic inflammatory disorders, as well as with many cancers. The causes underlying this age-associated inflammation, and how it leads to diseases, are poorly understood. New work in Carnegie’s Yixian Zheng’s lab sheds light on one protein’s involvement in suppressing immune responses in...
Baltimore, MD--The General Motors Corporation is presenting a $5,000.00 award to Carnegie’s BioEYES K-12 educational program on September 11, 2014, to deliver a two-week environmental curriculum, Your Watershed, Your Backyard. The program, established in 2008, is one of several BioEYES programs using live zebrafish in a hands-on approach to learning and focuses on local watersheds, pollution, and the Chesapeake Bay. The event includes other...
Baltimore, MD— A woman’s supply of eggs is a precious commodity because only a few hundred mature eggs can be produced throughout her lifetime and each must be as free as possible from genetic damage. Part of egg production involves a winnowing of the egg supply during fetal development, childhood and into adulthood down from a large starting pool. New research by Carnegie’s Alex Bortvin and postdoctoral fellow Safia Malki have gained new...
Audio Baltimore, MD—Exposure to environmental endocrine disrupters, such as bisphenol A, which mimic estrogen, is associated with adverse health effects. Bisphenol A is commonly found in plastic bottles and plastic food containers. New research from a team including Carnegie's Daniel Gorelick and Marnie Halpern on the effects of these chemicals on zebrafish shows that embryonic heart valves could be particularly in danger. It is published by...
YouTubeBaltimore, MD— As all school-children learn, cells divide using a process called mitosis, which consists of a number of phases during which duplicate copies of the cell's DNA-containing chromosomes are pulled apart and separated into two distinct cells. Losing or gaining chromosomes during this process can lead to cancer and other diseases, so understanding mitosis is important for developing therapeutic strategies. New research from a...
AudioBaltimore, MD— One classical question in developmental biology is how different tissue types arise in the correct position of the developing embryo. While one signaling pathway that controls this process has been well described, unexpected findings from a team led by Carnegie’s Steven Farber reveal the importance of polyunsaturated fatty acid metabolism in this process. It is published online December 12 in Developmental Cell. Fatty acids...
AudioBaltimore, MD—In researching neural pathways, it helps to establish an analogous relationship between a region of the human brain and the brains of more-easily studied animal species. New work from a team led by Carnegie’s Marnie Halpern hones in on one particular region of the zebrafish brain that could help us understand the circuitry underlying nicotine addiction. It is published the week of December 9 by Proceedings of the National...
Baltimore, MD--Cells in the body wear down over time and die. In many organs, like the small intestine, adult stem cells play a vital role in maintaining function by replacing old cells with new ones. Learning about the nature of tissue stem cells can help scientists understand exactly how our organs are built, and why some organs generate cancer frequently, but others only rarely. New work from Carnegie’s Alexis Marianes and Allan Spradling...
AudioBaltimore, MD—Proper tissue function and regeneration is supported by stem cells, which reside in so-called niches. New work from Carnegie’s Yixian Zheng and Haiyang Chen identifies an important component for regulating stem cell niches, with impacts on tissue building and function. The results could have implications for disease research. It is published by Cell Stem Cell.   Lamins are proteins are the major structural component of the...
Baltimore, MD—Mammalian females ovulate periodically over their reproductive lifetimes, placing significant demands on their ovaries for egg production. Whether mammals generate new eggs in adulthood using stem cells has been a source of scientific controversy. If true, these “germ-line stem cells” might allow novel treatments for infertility and other diseases. However, new research from Carnegie’s Lei Lei and Allan Spradling demonstrates that...
Baltimore, MD— Eggs take a long time to produce in the ovary, and thus are one of a body’s precious resources. It has been theorized that the body has mechanisms to help the ovary ensure that ovulated eggs enter the reproductive tract at the right time in order to maximize the chance of successful fertilization.   New research from Carnegie's Allan Spradling and Jianjun Sun has shed light on how successful ovulation and fertilization are brought...
Baltimore, MD--Recent research shows that natural experiences in childhood boost creativity, stimulate learning, and improve behavior and health. Carnegie’s BioEYES educational program, in partnership with General Motors (GM), is capitalizing on this by sponsoring some 25–30 middle-school students from Guilford Elementary/Middle School to plant native shrubs for a wildlife habitat area at the White Marsh, MD, GM operations facility on April 25,...
Baltimore, MD— The ability of embryonic stem cells to differentiate into different types of cells with different functions is regulated and maintained by a complex series of chemical interactions, which are not well understood. Learning more about this process could prove useful for stem cell-based therapies down the road. New research from a team led by Carnegie’s Yixian Zheng zeroes in on the process by which stem cells maintain their proper...
Washington, D.C.—The Carnegie Institution for Science and the University of Massachusetts Medical School (UMMS) have been granted United States Patent 8,283,329, entitled, “Genetic inhibition of double-stranded RNA.” The patent, issued on October 9, 2012, is broadly directed to the use of RNA interference (RNAi) to inhibit expression of a target gene in animal cells, including mammalian cells.   The process by which RNA, the cellular material...
Baltimore, MD —You may think you have dinner all to yourself, but you’re actually sharing it with a vast community of microbes waiting within your digestive tract. A new study from a team including Carnegie’s Steve Farber and Juliana Carten reveals that some gut microbes increase the absorption of dietary fats, allowing the host organism to extract more calories from the same amount of food.    Previous studies showed gut microbes aid in the...
Baltimore, MD—Director Emeritus Donald Brown, of Carnegie’s Department of Embryology, receives the prestigious 2012 Lasker-Koshland Special Achievement Award in Medical Science “For exceptional leadership and citizenship in biomedical science–exemplified by fundamental discoveries concerning the nature of genes; and by selfless commitment to young scientists.” Brown is honored along with Tom Maniatis of Columbia University.   Brown received his...
Baltimore, MD — The study of muscular system protein myostatin has been of great interest to researchers as a potential therapeutic target for people with muscular disorders. Although much is known about how myostatin affects muscle growth, there has been disagreement about what types of muscle cells it acts upon. New research from a team including Carnegie's Chen-Ming Fan and Christoph Lepper narrows down the field to one likely type of cell....
Baltimore, MD — In mammals, most lipids (such as fatty acids and cholesterol) are absorbed into the body via the small intestine. The complexity of the cells and fluids that inhabit this organ make it very difficult to study in a laboratory setting. New research from Carnegie’s Steven Farber, James Walters and Jennifer Anderson reveals a technique that allows scientists to watch lipid metabolism in live zebrafish. This method enabled them to...
Baltimore, MD — Insect glands are responsible for producing a host of secretions that allow bees to sting and ants to lay down trails to and from their nests. New research from Carnegie scientists focuses on secretions from glands in the reproductive tract that help sperm survive and guide the sperm on the trip to fertilize an egg. The gene that controls the development of these glands in fruit flies provides important information about gland...
Baltimore, MD—Carnegie’s educational outreach program, BioEYES, will be the recipient of the 2012 Viktor Hamburger Outstanding Educator Prize from the Society for Developmental Biology. BioEYES founders Steve Farber and Jamie Shuda (University of Pennsylvania), will accept the award at the upcoming annual meeting of the society in Montreal in July. BioEYES, with program manager Valerie Butler, is also currently featured in a video on the front...
Baltimore, MD — Scientists have long held theories about the importance of proteins called B-type lamins in the process of embryonic stem cells replicating and differentiating into different varieties of cells. New research from a team led by Carnegie’s Yixian Zheng indicates that, counter to expectations, these B-type lamins are not necessary for stem cells to renew and develop, but are necessary for proper organ development. Their work is...
Baltimore, MD—Carnegie’s educational outreach program, BioEYES, has joined forces with General Motors (GM), and Earth Force to take Walter P. Carter Elementary/Middle School students on a knee-deep watershed lesson on December 1, 2011. The group will monitor water quality, sample aquatic insects (indicators of stream health), go on a nature walk, and identify water problems in the Herring Run watershed near the school to teach students about...