Publications

1.     Zheng Y, Jung MK, & Oakley BR (1991). g-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome. Cell 65:817-823

2.     Zheng Y, Wong ML, Alberts B, & Mitchison TJ (1995). A g-tubulin ring complex from the unfertilized egg of Xenopus laevis can nucleate microtubule assembly in vitro. Nature 378:578-583. (News & Views: Oakley, Nature 378:555-556)

3.     Wilson PG, Zheng Y, Oakley CE, Oakley BR, Borisy GG, & Fuller MT (1997). Differential expression of two g-tubulin isoforms during gametogenesis and development in Drosophila. Developmental Biology 184:207-221

4.     Dictenberg JB, Zimmerman W, Sparks CA, Young A, Vidair C, Zheng Y, Carrington W, Fay FS, & Doxsey SJ (1998). Pericentrin and g-Tubulin Form a Protein Complex and Are Organized into A Novel Lattice at the Centrosome. Journal Cell Biology 141:163-174

5.     Martin O, Gunawardane R., Iwamatsu A, & Zheng Y (1998). Xgrip109: A g-tubulin associated protein with an essential role in gTuRC assembly and centrosome function. Journal of Cell Biology 141:675-687

6.     Moritz M, Zheng Y, Alberts B, & Oegema K (1998). Recruitment of the g-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds. Journal of Cell Biology 142:775-786

7.     Zheng Y, Wong ML, Alberts B, & Mitchison T (1998). Purification and assay of g-tubulin ring complex. Methods in Enzymology 298, Part B, 218-228

8.     Field CM, Oegema K., Zheng Y, Mitchison T, & Walczak CE (1998). Purification of Cytoskeletal Proteins Using Peptide Antibodies. Methods in Enzymology 298, Part B, 525-541

9.     Oegema K, Wiese C, Martin OC, Milligan RA, Iwamatsu A, Mitchison T, & Zheng Y (1999). Characterization of Two Related Drosophila g-tubulin Complexes that Differ in Their Ability to Nucleate Microtubules. Journal of Cell Biology 144:721-733

10.  Wiese C & Zheng Y (1999). g-Tubulin Complexes and Their Interaction with Microtubule Organizing Centers. Current Opinion in Structural Biology 9:250-259

11.  Wilde A & Zheng Y (1999). Stimulation of Microtubule Aster Formation and Spindle Assembly in Xenopus Egg Extracts by the Small GTPase Ran. Science 284:1359-1362. (News Focus: Pennisi, Science 284:1260-1261, 1999; Commentary: Desai & Hyman, Current Biology 9:R704-707, 1999)

12.  Wiese C & Zheng Y (2000). A New Function for the g-tubulin Ring Complex as a Microtubule Minus-end Cap. Nature Cell Biology 2:358-364. (News & Views: Erickson, Nature Cell Biology 2:E93-E96)

13.  Zhang L, Keating T, Wilde, A, Borisy G, & Zheng Y (2000). The Role of Xgrip210 in g-Tubulin Ring Complex Assembly and Centrosome Recruitment. Journal of Cell Biology 151:1525–1535

14.  Gunawardane R, Martin O, Cao K, Zhang L, Dej K, Iwamatsu A, & Zheng Y (2000). Characterization and Reconstitution of Drosophila g-Tubulin Ring Complex Subunits. Journal of Cell Biology 151:1513–1523

15.  Gunawardane RN, Lizarraga SB, Wiese C, Wilde A, & Zheng Y (2000). g-Tubulin Complexes and Their Role in Microtubule Nucleation. Current Topics in Developmental Biology 49:55-73.

16.  Wilde A, Lizarraga S, Zhang L, Wiese C, Gliksman N, Walczak C, & Zheng Y (2001). Ran stimulates spindle assembly by changing microtubule dynamics and the balance of motor activities. Nature Cell Biology 3:221-227. (News & Views: Walczak, Nature Cell Biology 3:E69-70, 2001)

17.  Wiese C, Wilde A, Adam S, Moore M, Merdes A, & Zheng Y (2001). Role of Importin-b in Coupling Ran to Downstream Targets in Microtubule Assembly. Science 291:653-656. (News & Views: Walczak, Nature Cell Biology 3:E69-70, 2001)

18.  Gunawardane RN, Zheng Y, Oegema K, & Wiese C (2001). Purification and reconstitution of Drosophila gamma-tubulin complexes. Methods in Cell Biology 67:1-25

19.  Lizarraga SB, Zheng Y, & Wilde AR (2002). Characterization of the effects of RanGTP on the microtubule cytoskeleton. Methods in Molecular Biology 189:247-260

20.  Gunawardane R, Martin OC, & Zheng Y (2003). Characterization of a new gTuRC subunit with WD repeats. Molecular Biology of the Cell 14:1017-1026

21.  Tsai MY, Wiese C, Cao K, Martin OC, Donovan P, Ruderman J, Prigent C, & Zheng Y (2003). A Ran-signaling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nature Cell Biology 5:242-248

22.  Li HY, Wirtz D, & Zheng Y (2003). A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo. Journal of Cell Biology 160:635-644

23.  Li HY, Cao K, & Zheng Y (2003) Ran in spindle checkpoint: a new function for a versatile GTPase. Trends in Cell Biology 13:553-557

24.  Cao K, Nakajima R, Meyer HH, & Zheng Y (2003). The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. Cell 115:355-367. (Highlight: Nature Reviews Molecular Cell Biology 4:906, 2003; Commentary: Cheeseman and Desai, Current Biology 14:R70-72, 2004)

25.  Ems-McClung SC, Zheng Y, & Walczak CE (2004). Importin / and Ran-GTP Regulate XCTK2 Microtubule Binding through a Bipartite Nuclear Localization Signal. Molecular Biology of the Cell 15:46-57

26.  Kawaguchi S & Zheng Y (2004). Characterization of a Drosophila Centrosome Protein CP309 That Shares Homology with Kendrin and CG-NAP. Molecular Biology of the Cell 15:37-45

27.  Li HY & Zheng Y (2004). Mitotic phosphorylation of RCC1 is essential for RanGTP gradient production and spindle assembly in mammalian cells. Genes and Development 18:512-527

28.  Cao K & Zheng Y (2004). The Cdc48/p97-Ufd1-Npl4 Complex: Its Potential Role in Coordinating Cellular Morphogenesis during the M-G1 Transition. Cell Cycle 3:422-424

29.  Li HY & Zheng Y (2004). The Production and Localization of GTP-Bound Ran in Mitotic Mammalian Tissue Culture Cells. Cell Cycle 3:993-995

30.  Ducat DC & Zheng Y (2004). Aurora kinases in spindle assembly and chromosome segregation. Experimental Cell Research 301:60-67

31.  Nakajima, R, Tsai, M-Y, & Zheng Y (2004). Centrosomes and Microtubule Nucleation. Encyclopedia of Biological Chemistry 1:372-376. W. J. Lennarz and M. D. Lane (Ed), Elsevier Inc.

32.  Zheng Y (2004). G Protein Control of Microtubule Assembly. Annual Review of Cell and Developmental Biology 20:867-894

33.  Tsai M-Y & Zheng Y (2005). Aurora A Kinase-Coated Beads Function as Microtubule-Organizing Centers and Enhance RanGTP-Induced Spindle Assembly.  Current Biology 15:2156-2163. (Highlighted in Meeting Report: Nuclear protein supports spindle. Journal of Cell Biology 172:488, 2006)

34.  Vong QP, Cao K, Li HY, Iglesias PA, & Zheng Y (2005). Chromosome Alignment and Segregation Regulated by Ubiquitination of Survivin. Science 310:1499-1504. (Perspective: Earnshaw, Science 310:1443-1444)

35.  Tsai M-Y, Wang S, Heidinger JM, Shumaker D, Adam SA, Goldman RD, & Zheng Y (2006). A Mitotic Lamin B Matrix Induced by RanGTP Required for Spindle Assembly. Science 311:1887-1893. (News & Views: Hayes, Nature Cell Biology 8:550, 2006; Research Highlight: Nature Reviews Molecular Cell Biology 7:307, 2006).

36.  Goodman B & Zheng Y (2006). Mitotic spindle morphogenesis: Ran on the microtubule cytoskeleton and beyond.  Biochemical Society Transactions 34:716-721

37.  Wiese C & Zheng Y (2006). Microtubule nucleation: g-tubulin and beyond. Journal of Cell Science 119:4143-4153

38.  Zheng Y & Tsai M-Y (2006). The Mitotic Spindle Matrix: A Fibro-Membranous Lamin Connection. Cell Cycle 5:2345-2347

39.  Spradling AC & Zheng Y (2007). The Mother of All Stem Cells? Science 315:469-470

40.  Liu Z, Vong QP, & Zheng Y (2007). CLASPing Microtubules at the trans-Golgi Network. Developmental Cell 12:839-840

41.  Li HY, Ng WP, Wong CH, Iglesias PA, & Zheng Y (2007). Coordination of Chromosome Alignment and Mitotic Progression by the Chromosome-Based Ran Signal. Cell Cycle 6:1886-1895

42.  Channels WE, Nedelec FJ, Zheng Y, & Iglesias PA (2008). Spatial regulation improves anti-parallel microtubule overlap during mitotic spindle assembly. Biophys Journal 94:2598-2609

43.  Zheng Y & Oegema K (2008). Cell Structure and Dynamics. Current Opinion in Cell Biology 20:1–3

44.  Ducat D, Kawaguchi S, Liu H, Yates JR 3rd, & Zheng Y (2008). Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase Pontin. Molecular Biology of the Cell 19:3097-3110

45.  Wilde A & Zheng Y (2009). Ran out of the nucleus for apoptosis. Nature Cell Biology 11:11-12

46.  Li M, Tsai MY, Lu B, Chen R, Yates III JR, Zhu X, & Zheng Y (2009).  A Requirement of Nudel and Dynein for Spindle Matrix Assembly during Spindle Morphogenesis. Nature Cell Biology 11:247-256

47.  Martin O, DeSevo CG, Guo BZ, Koshland DE, Dunham MJ, & Zheng Y (2009). Telomere behavior in a hybrid yeast. Cell Research 19:910-912

48.  Liu Z & Zheng Y (2009).  A Requirement for Epsin in Mitotic Membrane and Spindle Organization. Journal of Cell Biology 186:473-480

49.  Bembenek JN, White JG, & Zheng Y (2010). A Role for Separase in the Regulation of RAB-11-positive Vesicles at the Cleavage Furrow and Midbody. Current Biology 20:259-264. (Commentary: Lopez-Aviles S and Uhlmann F, The Art of Multi-Tasking, Current Biology 20:R101-103, 2010)

50.  Wallingford JB, Liu KJ, & Zheng Y (2010). Xenopus. Curr Biol 20:R263-4

51.  Vong QV, Liu Z, Yoo JG, Chen R, Xie W, Sharov AA, Fan CM, Liu C, Ko MSH, & Zheng Y (2010).  A Role for Borg5 during Trophectoderm Differentiation. Stem Cells 28:1030-1038

52.  Zheng Y (2010). Mitotic spindle matrix may hold the answer to orchestrating cell division. Nature Reviews Molecular Cell Biology 11:529-535

53.  Goodman B, Channels W, Qiu M, Iglesias P, Yang G, & Zheng Y (2010). Lamin-B3 counteracts the kinesin Eg5 to restrain spindle pole separation during spindle assembly. J Biol Chem 285:35238-44

54.  Poirier CC, Zheng Y, & Iglesias PA (2010). Biophysical J. Mitotic Membrane Helps to Focus and Stabilize the Mitotic Spindle. Biophys J 99:3182-3190

55.  Hoang ML, Tan FJ, Lai DC, Celniker SE, Hoskins RA, Dunham MJ, Zheng Y, Koshland D (2010). Competitive Repair by Naturally Dispersed Repetitive DNA during Non-Allelic Homologous Recombination. PLoS Genet 6(12):e1001228

56.  Wang S & Zheng Y (2011). Identification of a novel dynein-binding domain in Nudel essential for spindle pole organization in Xenopus egg extracts. J Biol Chem 286:587-93

57.  McDole K, Xiong Y, Iglesias PA, Zheng Y (2011). Lineage mapping the pre-implantation mouse embryo by two-photon microscopy, new insights into the segregation of cell fates. Dev Biol. 355:239-49.

58.  Kang J, Goodman B, Zheng Y, & Tantin D (2011). Dynamic Regulation of Oct1 during Mitosis by Phosphorylatino and Ubiquitination. PloS One, Vol. 6, Issue 8, e23872.

59.  Kim Y, Sharov AA, McDole K, Cheng M, Hao H, Fan C-M, Gaiano N, Ko MSH, &  Zheng Y.  Mouse ES cells do not need any lamins but proper organogenesis requires lamin-Bs. Science 334:1706-10.

60.  Liu Z, Vong Q, Liu C, and Zheng Y. The Cdc42 effector protein Borg5 Regulates Dynamic Cell-cell Adhesion in the Cardiac Microvasculature. Submitted.

61.  Jia J, Zheng X, Hu G, Cui K, Zhang A, Zhang J, Du Y, Liu C, Zhao K, and Zheng Y.  Utf1 promotes development and proliferation by regulating bivalent chromatin state and mRNA turnover. Submitted.